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Multivitamin + 15 mg L-Methylfolate

30 CAPS | 15 mg Product No. 00818


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This one-a-day capsule was designed to meet the nutritional priorities of patients looking for high dose L-methylfolate that includes a well-rounded multivitamin/mineral complex. L-methylfolate is the bioactive form of folate used in the normal production of neurotransmitters and in the conversion of homocysteine to methionine. At least half of the global population are unable to properly convert folic acid to this usable, active form of folate. For this group especially, supplementing with L-methylfolate is a superior nutritional choice to support healthy neurotransmitter production and methylation throughout the body.

The Multivitamin + 15 mg L-Methylfolate also provides a spectrum of essential daily nutrients in their most bioavailable forms to support a balanced mood, reliable energy, immune health, and more. This formula also includes important cofactors for the methylation process such as vitamin B-12, vitamin B-6, and choline.

  • Conveniently provides 15 mg L-methylfolate in a complete multivitamin
  • Supports the formation of mood balancing neurotransmitters
  • Promotes healthy energy levels with a full array of B vitamins
  • Supports healthy immune function with zinc, vitamin C, and 2000 IU of vitamin D

* These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

   MethylPro® Multivitamin + 15 mg L-Methylfolate


Product Code: 00818     Capsules per Bottle: 30  


Each size 00 vegetarian cellulose capsule contains:


Vitamin A (as Palmitate)

900 mcg RAE

Vitamin C (as Ascorbic Acid and Ascorbyl Palmitate)

150 mg

Vitamin D-3 (2000 IU as Cholecalciferol)

50 mcg

Vitamin E (as d-Alpha Tocopheryl Acid Succinate)

67 mg

Vitamin K (as K-1 and K-2 M7)

100 mcg

Thiamine (as Thiamine Mononitrate)

10 mg

Riboflavin (as Riboflavin 5’ Phosphate)

10 mg

Niacin (as Niacinamide)

50 mg NE

Vitamin B-6 (as Pyridoxal 5’ Phosphate)

10 mg

Folate (as 15 mg from 20.5 mg L-5-Methylfolate, calcium salt)

25 mg DFE

Vitamin B-12 (as Methylcobalamin)

1000 mcg


100 mcg

Pantothenic Acid (as Calcium D-Pantothenate)

50 mg

Iodine (as Potassium Iodide)

100 mcg

Zinc (as Zinc Citrate)

15 mg

Selenium (as L-Selenomethionine)

100 mcg

Manganese (as Manganese Gluconate)

5 mg

Chromium (as Chromium Niacinate)

100 mcg

Choline bitartrate

55 mg

Molybdenum (as Molybdenum Glycinate)

75 mcg

Vitamin D is derived from lanolin. Natural vitamin E is derived from soy oil.

Other ingredients: vegetarian cellulose capsule


Description: The Multivitamin + 15 mg L-Methylfolate is a one-a-day answer to common nutritional needs of our MethylPro customers. It provides our most popular potency of L-methylfolate with a well-rounded multivitamin. The MethylPro® Multivitamin will leave you prepared to meet the unpredictable demands of your day by providing essential nutrients to support balanced mood, reliable energy and immune health functions.

Unlike folic acid, the most common form of folate in supplements and fortified foods, L-methylfolate, does not require conversion by the MTHFR enzyme to be active in the body. A significant number of people have genetic variations that reduce the ability of the MTHFR enzyme to make this conversion. For this population, L-methylfolate supplementation may be a more effective form of folate.



Mood and Energy Support

Mood: L-methylfolate provides folate in a highly bioavailable form that is able to cross the blood brain barrier. L-methylfolate is important for the normal production of mood-balancing neurotransmitters including serotonin, norepinephrine and dopamine. Low levels of vitamin D and B12 have been associated with an increased risk of low mood.

Energy: The B vitamins thiamine, riboflavin, niacinamide, B-6, biotin and pantothenic acid are cofactors for enzymes needed for cellular energy production through metabolism of proteins, carbohydrates, and fats

Methylation Support: Methylation is a biochemical process involved in almost all the body’s functions. It is the addition of a single carbon and three hydrogen atoms (called a methyl group) to another molecule. Methylation is an important process in neurotransmitter production, DNA regulation and liver detoxification processes. This vitamin provides important support for methylation pathways including methyl donors and cofactors like folate, choline, B6, B12 and riboflavin.

Immune Support: MethylPro Multivitamin + 15 mg L-Methylfolate contains top nutrients involved in positive immune function including Vitamins A, C and D and zinc. Vitamin C and A are known for their positive effects on the human immune response and recent studies have shown a brighter light on vitamin D‘s important immune modulating activities. Zinc is a mineral required for several immune functions including healthy T lymphocyte activity.

Nutritional Support: MethyPro Multivitamin + 15 mg L-Methylfolate is a one-per-day multivitamin/mineral capsule containing key nutrients in their most bioavailable forms. Methyl Pro formulas contain the highest quality activated nutrients with no non-nutritive additives.

Source Materials: L-methylfolate, calcium salt (Extrafolate S®, Gnosis Bio, Italy) is made by chemical synthesis.

Vitamin A palmitate, thiamine mononitrate, niacinamide, pyridoxal 5 phosphate, L-methylfolate, biotin, and pantothenic acid: synthetic. Ascorbic acid: corn sorbitol. Ascorbyl palmitate: ascorbic acid from corn and palmitic acid from palm oil. Vitamin D3: lanolin from sheep’s wool. Vitamin E succinate: purified soy oil. Riboflavin 5 phosphate and methylcobalamin: dextrose fermentation. Minerals are mined. Chelating agents include: glycine (synthetic), citric acid (corn fermentation), methionine (synthetic), glucuronic acid (synthetic). Cellulose for capsules is derived from softwood tree pulp. There is no detectable GM material present.

Allergens:  According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.


Recommendations: Use as directed by a healthcare professional.


Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.



  1. LeBano, Lauren. “L-Methylfolate: A Promising Therapy for Treatment-Resistant Depression?” Psyche Congress Network. May 8, 2013. www.psychcongress.com/article/l-methylfolate-promising-therapy-treatment-resistant-depression
  2. Leech, Joe. “L-Methylfolate (5-MTHF): Your Must-Read Beginner’s Guide.” Diet vs. Disease. May 13, 2018. https://www.dietvsdisease.org/l-methylfolate-5-mthf/
  3. Papakostas, George I., et al. "L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials." American Journal of Psychiatry 169.12 (2012): 1267-1274.
  4. Patanwala, Imran, et al. "Folic acid handling by the human gut: implications for food fortification and supplementation–."The American journal of clinical nutrition 100.2 (2014): 593-599.
  5. Stahl, Stephen M. "Brainstorms: L-Methylfolate: A Vitamin for Your Monoamines." The Journal of clinical psychiatry 69.9 (2008): 1352-1353.
  6. Rondanelli, Mariangela, et al. "Self-care for common colds: the pivotal role of vitamin D, vitamin C, zinc, and Echinacea in three main immune interactive clusters (physical barriers, innate and adaptive immunity) involved during an episode of common colds—Practical advice on dosages and on the time to take these nutrients/botanicals in order to prevent or treat common colds." Evidence-Based Complementary and Alternative Medicine 2018 (2018).
  7. Pham-Huy, Lien Ai, Hua He, and Chuong Pham-Huy. "Free radicals, antioxidants in disease and health." International journal of biomedical science: IJBS 4.2 (2008): 89.
  8. Chesney RW. “Vitamin D and The Magic Mountain: the anti-infectious role of the vitamin.” JPediatr (2010) 156:698-703. 



These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Multivitamin + 15 mg L-Methylfolate

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