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L-Methylfolate 10 mg

30 CAPS Product No. 00806

$21.00

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Based on scientific research, our L-methylfolate is a more active and bioavailable form of folate and is the only form of folate to cross the blood-brain barrier. L-methylfolate is important for normal production of serotonin, norepinephrine, and dopamine, and is essential for converting homocysteine to methionine. Almost half of all people have genetic variations that reduce their ability to convert folate to its usable form. For this population, L-methylfolate supplementation is far more effective in providing this form of folate. Use it to help support healthy mood, cardio, and nerve function.

  • Supports the production of mood balancing neurotransmitters.
  • Provides most effective form of folate for those with genetic MTHFR variations.
  • Offered in several strengths.

*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

L-Methylfolate 10 mg

 

Product Code: 00806              Capsules per Bottle: 30

 

Each size 3 vegetarian cellulose capsule contains:

 

Folate (10 mg folate from 13.7 mg L-5-Methylfolate, calcium salt)

16.7 mg DFE

Glycine

260 mg

 

Description: L-methylfolate is the activated form of folate found in food and used by the body for many biochemical reactions. Unlike folic acid, L-methylfolate does not require conversion by the MTHFR enzyme, a function that is impaired by genetic variations present in about half the population.

 

Uses: L-methylfolate is critical for biochemical reactions involving one-carbon transfer (methylation). These include: DNA synthesis, cell division, amino acid metabolism and neurotransmitter synthesis. Studies suggest low folate levels can contribute to depressed mood and that supplementation may be useful for maintenance of healthy moods. A decline in folate levels in the cerebral spinal fluid occurs with aging, and has been associated with reduced cognitive function. L-methylfolate is essential for the conversion of homocysteine to methionine, supporting vascular and cardio health by lowering homocysteine levels.

 

Source Materials: L-methylfolate, calcium salt (Extrafolate S®, Gnosis Bio, Italy) and glycine are made by chemical synthesis. All ingredients are vegan and non-GMO.

 

Allergens:  According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.

 

Recommendations: Use as directed by a healthcare professional.

 

Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.

 

References:

 

  1. Ginsberg LD et al. L-methylfolate plus SSRI or SNRI from treatment initiation compared to SSRI or SNRI monotherapy in a major depressive episode. Innovations in Clinical Neuroscience. 2011 Jan;8(1): 19-28
  2. Zajecka JM et al. Long-term efficacy, safety, and tolerability of L-methylfolate calcium 15 mg as adjunctive therapy with selective serotonin reuptake inhibitors: a 12 month, open-label study following a placebo-controlled acute study. J Clin Psychiatry. 2016 May; 77(5): 654-60.
  3. Araujo JR et al. Folates and aging: role in mild cognitive impairment, dementia and depression. Ageing Res Rev. 2015 Jul; 22:9-19.
  4. Ambrosino P et al. Cyclic supplementation of 5-MTHF is effective for the correction of hyperhomocysteinemia. Nutr Res. 2015 Jun; 35(6):489-95
  5. Cagnacci A et al. High-dose short-term folate administration modifies ambulatory blood pressure in postmenopausal women. A placebo controlled study. Eur J Clin Nutr. 2009 Oct; 63(10):1266-8.

 

 

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

L-Methylfolate 10 mg

Supports normal healthy mood, cardio and nerve function.* *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

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