Product Code:00800 Capsules per Bottle: 90
Each size 3 vegetarian cellulose capsule contains:
L-5-methylfolate, calcium salt
L-methylfolate is the activated form of folate found in food and used by the body for many biochemical reactions. Folate supports mood, heart, and nerve health as well as normal fetal development. Unlike folic acid, L-methylfolate does not require conversion by the MTHFR enzyme, a function that may be impaired by genetic variations present in about half the population. This product provides the bioactive form of folate in a 1 mg dose suitable for a broad array of supplementation needs regardless of MTHFR status.
How does it work?
L-methylfolate is critical for biochemical reactions involving one-carbon transfer (methylation). These include: DNA synthesis, cell division, amino acid metabolism, and neurotransmitter synthesis. Studies suggest that low folate levels can contribute to depressed mood and that supplementation may be useful for the maintenance of healthy moods. A decline of folate levels in the cerebral spinal fluid occurs with aging and has been associated with reduced cognitive function. L-methylfolate is essential for the conversion of homocysteine to methionine, supporting vascular and cardio health by supporting normal homocysteine levels.
Folate supplement: Adequate folate is necessary for the normal formation of red blood cells and proper nerve function. Folate needs may be increased in those on medications known to decrease folate levels including certain anticonvulsants, oral contraceptives and certain medications used to regulate blood sugar.
Universal folate nutritional support: Useful folate levels may be affected in a certain percentage of the population with the MTHFR gene polymorphisms. While daily MTHFR polymorphism folate needs are seen as falling within the same guidelines as supplemental needs for the general population, L-5-MTHF, as a form of folate that bypasses the MTHFR enzyme, may be a more readily usable form for this population and is a bioavailable source of folate safe for all segments of the population.
Women of childbearing years: Folate is a necessary nutrient for normal fetal development. It is advised that women of childbearing years take extra steps to ensure their folate needs are met. Breastfeeding mothers also have increased folate needs.
Mood: L-methylfolate supports the formation of neurotransmitters necessary for balanced mood including serotonin, dopamine and norepinephrine.
Source Materials: L-5-methylfolate, calcium salt: synthetic. Glycine: synthetic. Cellulose for capsules is derived from softwood tree pulp.
Allergens: According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.
Recommendations: 1 capsule per day or as directed by a healthcare professional.
Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.
- Refsum H, Nurk E, Smith AD, et al. The Hordaland homocysteine study: a community-based study of homocysteine, its determinants and associations with disease. J Nutr. 2006; 136: 1731S-40S.
- Martinez Figueroa A, Johnson RH, Lambie DG, Shakir RA. The role of folate deficiency in the development of peripheral neuropathy caused by anticonvulsants. J Neurol Sci. 1980 Dec;48(3):315-23.
- Wulffele MG, Kooy A, Lehert P, et al. Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial. J Intern Med. 2003; 254: 455-463.
- Wilson SM, Bivens BN, Russel KA, Bailey LB. Oral contraceptive use: impact on folate, B6 and vitamin B 12 status. Nutr Rev. 2011 Oct; 69(10): 572-83.
- Nishio K, Goto Y, Hamajima N, et al. Serum folate and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism adjusted for folate intake. J Epidemiol. 2008; 18(3): 125-131.
* These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.