Folate is important for the normal production of the mood balancing neurotransmitters serotonin, norepinephrine and dopamine. Folic acid is the most common form of folate in supplements and fortified foods but it needs to be converted to methylfolate to be used by the body for neurotransmitter communication and many other important biochemical reactions. This process is done by the enzyme, methylenetetrahydrofolate reductase (MTHFR). Unfortunately, about half the population have genetic variations that reduce the ability of the MTHFR enzyme to convert folic acid to its usable form, methylfolate. Because supplementing with L-methylfolate removes the need for this conversion, it is far more effective than its inactivated counterparts.