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L-Methylfolate 15 mg

90 CAPS | 15 mg Product No. 00811


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L-Methylfolate is the bioavailable form of folate and is the only form able to cross the blood-brain barrier. L-Methylfolate is important for normal production of serotonin, norepinephrine and dopamine, and is essential for converting homocysteine to methionine. Almost half of all people have genetic variations that reduce their ability to convert folate to its usable form. For this population, L-methylfolate supplementation is far more effective in providing this form of folate. Use it to help support healthy mood, cardio, and nerve function.


  • Supports the production of mood balancing neurotransmitters.
  • Provides most effective form of folate for those with genetic MTHFR variations.
  • Offered in several strengths.


*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

L-Methylfolate, 15 mg


Product Code:   00811         Capsules per Bottle: 90


Each size 3 vegetarian cellulose capsule contains:


Folate (15 mg from 20.5mg L-5-Methylfolate, calcium salt)

25 mg DFE


250 mg


Product Details:  


Folate (vitamin B-9) is an essential vitamin, often added to fortified foods or supplemented in its synthetic form, folic acid. The problem with folic acid is that it must be converted by the body into L-methylfolate before it can provide any benefits. About half of the global population has inherited genetic variations that make this conversion inefficient. The consequences typically manifest as difficulty balancing mood and energy levels, or pathologies related to high homocysteine.


For most people, L-methylfolate supplements are a superior alternative to folic acid. L-Methylfolate is highly bioavailable and delivers the benefits of active folate to everyone. L-Methylfolate is not exclusively for those with an MTHFR mutation, however, it can raise circulating levels of activated folate for those individuals in a way that folic acid cannot.


What is L-Methylfolate?


L-Methylfolate is the active form of folate (vitamin B-9). 


Low folate status is one of the most common nutritional deficiencies and that statistic increases with age [1]. Lack of dietary folate is the primary reason for this deficiency, but interfering health issues can prevent natural folate absorption, and some people are born without the ability to metabolize folic acid properly. 


To combat widespread folate deficiency, food manufacturers began “fortifying” food by adding synthetic folic acid to common foods (white rice, bread, etc.) that don’t contain much folate naturally. Once ingested, folic acid must be converted to L-methylfolate, the active form of folate, before it can be used by the body for many biochemical reactions. 


This conversion requires the body to produce an enzyme called methylenetetrahydrofolate reductase (MTHFR). Unfortunately, about half of the population has genetic variations that significantly reduce the ability of the MTHFR enzyme to make this conversion. This means some people cannot make enough active folate to fulfill their physiological needs, no matter how much folic acid they consume [2]. 

Unmetabolized synthetic folic acid can also build up in the bloodstream, causing adverse effects, especially in the elderly [3]. Folic acid is much slower to break down than natural folate, even in individuals with healthy folate metabolism. It also requires the help of the liver and other tissues for activation. 


Replacing folic acid supplements with L-methylfolate is a healthy choice for all individuals, regardless of age or genetic predisposition. L-methylfolate completely bypasses the entire folic acid metabolism cycle and has been shown to be more effective than folic acid for increasing circulating active folate in the body [4].


What does L-Methylfolate do in the body? 


L-Methylfolate is critical for biochemical reactions involving methylation. Methylation processes include DNA synthesis, cell division, amino acid metabolism, and neurotransmitter synthesis. 

L-Methylfolate is required to convert the amino acid homocysteine to another amino acid, methionine. The body uses methionine to make the neurotransmitters dopamine, serotonin, melatonin, and epinephrine. 


Shortages in these neurotransmitters are often related to major depression and other psychiatric disorders. While SSRI medicines work by blocking the reabsorption of neurotransmitters, L-methylfolate can support healthier production levels of the needed neurotransmitters for balanced mood and energy [5].


Without sufficient L-methylfolate, homocysteine levels can build up, causing a potentially serious condition known as hyperhomocysteinemia. This is a known, independent risk factor for heart disease, stroke, and other forms of cardiovascular disease [6]. 


A decline in folate levels in the cerebrospinal fluid occurs with aging and has been associated with reduced cognitive function [7]. High homocysteine is also associated with an increased risk for both cognitive decline and dementia [5]. It is possible then, that supplementing L-methylfolate, which keeps folate status up and homocysteine levels down, may support cognitive longevity and mental clarity in our later years.


If your nutritional supplement delivers folate in the form of L-methylfolate, your body can use the nutrient for its various purposes immediately upon absorption, rather than relying on the folic acid cycle and all of the other precursors to activate folic acid. L-Methylfolate is highly effective at reducing homocysteine levels (with or without an MTHFR mutation) [6]. 


Suggested Uses for L-Methylfolate

  • Folate supplement: Adequate folate is necessary for the normal formation of red blood cells and proper nerve function. Folate needs may be increased in those on medications known to decrease folate levels including certain anticonvulsants, oral contraceptives, and certain medications used to regulate blood sugar.
  • Universal folate nutritional support: L-methylfolate/L-5-MTHF, is a bioavailable source of folate safe for all segments of the population. As a form of folate that bypasses the MTHFR enzyme, it may be a more readily usable form for the portion of the population with MTHFR polymorphisms.
  • Women of childbearing years: Folate is a necessary nutrient for normal fetal development. It is advised that women of childbearing years take extra steps to ensure their folate needs are met. Breastfeeding mothers also have increased folate needs.
  • Mood: L-methylfolate supports the formation of neurotransmitters necessary for a balanced mood including serotonin, dopamine, and norepinephrine.

Source Materials: L-5-methylfolate, calcium salt: synthetic. Glycine: synthetic. Cellulose for capsules is derived from softwood tree pulp.


Allergens: According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.


Recommendations: 1 capsule per day or as directed by a healthcare professional.


Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.



  1. Clarke, Robert, et al. "Vitamin B12 and folate deficiency in later life." Age and ageing 33.1 (2004): 34-41.
  2. Kaiser Permanente. “Basic Information About the MTHFR Gene.” The Permanente Medical Group, Inc. Copyright 2015, last reviewed 2018. 
  3. Hauser, W. Allen. "Folic acid supplementation: too much of a good thing?." Journal of Neurology, Neurosurgery & Psychiatry 80.5 (2009): 468-468.
  4. Greenberg, James A., et al. "Folic acid supplementation and pregnancy: more than just neural tube defect prevention." Reviews in Obstetrics and Gynecology 4.2 (2011): 52.
  5. Papakostas, George I., et al. "L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials." American Journal of Psychiatry 169.12 (2012): 1267-1274.
  6. Lamers, Yvonne, et al. "Supplementation with [6 S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women." The American journal of clinical nutrition 79.3 (2004): 473-478.
  7. McCaddon, Andrew, and Peter R. Hudson. "L-methylfolate, methylcobalamin, and N-acetylcysteine in the treatment of Alzheimer's disease-related cognitive decline." CNS spectrums 15.S1 (2010): 2-5.






These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.



L-Methylfolate 15 mg

Supports normal healthy mood, cardio and nerve function.* *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

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  • Kathryn Sharp

    2021-10-25 11:11 am

    This is a good company to work with. And I'm finding that the methylfolate is helping me think much more clearly. (I have ADHD.) I still need other medication, but am very happy with what this does for me. Thank you, MethylPro!

  • Nancy Brienzo

    2021-04-04 02:30 pm

    Since being put on Lmethol Folate per advise Mayo Clinic Pharmacist my HGB has returned to normal in combonation with B12 injections every 2 weeks. My NEW doctor did a blood test and I do not make the "intrensic factor" in my stomach to absorb regular folate acid. B12 injections had my HGB up to about 9 to 10 but I was still dizzy, unsteady gait, tired easily, pain. With the addition of this type of folic acid I can absorb with 6 months my HBG climbed to 13.9! Hasnt been that high for 15 years starting at age 50. My thyroid also needed to be removed. Benign tumors! I have 3 sisters and we all stuggled starting early 40s. We all had thyroid trouble, B12 deficiency (all of us do not have ability to absorb folate acid from food. All on B12 shots. All start this c9mpany's brand of L-Methol Folate 15mg every morning before food. ALL OF US HAVE IMPROVED OUR HGB & ALL SYMPTOMS HAVE ABATED. All have had thyroids removed as well).

    Recently DX with inflamatory disease & being treated by Rheumatogist with Hydroxychoraphine 200mg 2 x day. I feel

    Alive again and am active after years of being too tired and in pain to get off couch for long periods. I am 65 and feel like I did almost when 25 years 6 months into taking this type of folate. Im absorbing B vitamins again. Will never be able to be off B12 shots but thats Ok as long as I feel this good. I cant live without this product. I am not a crock. Am highly educated nurse.

  • Jodi Volz

    2020-08-17 02:33 pm

    Please Keep this in a fair range. This is an excellent product and I know alot of people are benefiting from using it. My insurance doesn't cover it. I would rather get it directly from the company if it helps them vs gouging from amazon.

  • Brenda Marciniszyn

    2020-04-27 12:10 pm

    I admit I am bipolar. My doctor suggested this along with the other medicine I take for this condition. I noticed a good change within a few days. It was an Rx at one time but now insurance won't pay, so I came here and I'll be here for a long time. Thank you for such a quality product that works.

  • Maeve Horgan

    2020-02-13 01:00 pm

    I keep waking up with a smile on my face. I have meditated for years, do yoga, have a bunch of happiness practices, however my RA medications often take their tole on my body and my happiness levels. Ever since taking these I feel lighter and am not craving sugars (what I often rely upon for boosting the happy chemicals), Thanks

  • teresa jensen

    2019-08-15 11:05 pm

    I have the genetic inability to process regular folic acid and developed depression and neuropathy in my feet in my late 50's. I take the 15 mil. of Mythel folate on my doctor's prescription and it makes a huge difference in nerve pain in my feet. I think the neuropathy has stopped advancing, as well. My son in his 30s take a lesser dose in the hope of not developing neuropathy as he too has the genetic problem. it does not seem to help my depression but SAMe does wonders for that. Also prescribed by my doctor.

  • Christin Gallo

    2019-08-11 10:45 am

    A simple blood test revealed I needed to take the bio available form of folate. My MD prescribed Deplin and to my surprise it has successfully helped keep me from spiraling into episodes of severe depression. However Pharmaceutical companies have kept the price of Deplin way too high, (is anyone surprised?). That was when I discovered Methylfolate is available on line and at a very reasonable cost. My severe depression has lifted, even our cold, dreary, grey winters don’t start me on another downward spiral. Finally, I can honestly say I’m once again enjoying life! For me, antidepressants and folate have proven to be a winning combination.

  • Kassie Fulmer

    2018-08-19 04:47 am

    Over the years, my short term memory had progressively diminished and caused significant stress, especially at work as a teacher. I’ve been taking medications for Bipolar II, MDD, and ADD (I know, I’m a mess) for over a decade and last year when I brought it up with my psychiatrist, he said that one of my medications actually blocks the ability of the brain to absorb folate, and gave me a week sample of 15mg Deplin . It was absolute night and day difference, but my insurance wouldn’t cover it because they consider a “medical food” to be a non-medically necessary nutritional supplement (because of course they’re the experts). So after months of trying to get by with the maximum strength you can buy at stores like GNC (1,000 mcg = 1 mg), I finally found this site, and it’s been life-changing. I’m not a fan of statements like that, but for something that keeps me from getting resented by my team for what they think is forgetfulness or even apathy, and helps me to stay on point while teaching by maintaining my sequential working memory, I can’t really describe it any other way. I’m so thankful I was able to find this.

  • Micah Bennett

    2018-06-27 08:06 am

    A few years back I was able to sample the Rx version of this under the name Deplin. It is very expensive and not covered by most insurance. I was happy to find and try the products from Methylpro. Having been on the 15mg for 90 days, and running out before I placed a new order, I can definitely tell a difference in my mood in the past few days without it. I have struggled with anxiety and depression for years and this product is a great addition to my other Dr. prescribed medications to combat those conditions. I will not run out again.

  • Sandy Turner

    2018-06-01 06:34 am

    I've been taking this for over a year. Can't say it helps with my mood, but has significantly helped with sleep. My Dr. recommended it and said it would take a month or so and I would probably have mood changes till then. I did not feel any mood changes. But sleep improved immediately which helps with the mood. I also had genetic testing done that showed low Methyl Folate.

  • Greta Quintin

    2018-05-15 06:02 pm

    It’s life changing. Not only does it significantly help my mood, it helps my skin. It’s the only thing that keeps my Keratosis pilaris (chicken skin) at bay. Also helps keep my skin clear from breakouts. I’ve tried a couple of the cheap brands on Amazon - big mistake. Don’t waste your money. They don’t work. My skin went to hell and so did my mood. Do yourself a solid and invest in the real stuff, MethylPro. You are worth it.

    My son also uses this and swears by it. When we had the cheap stuff he didn’t know the difference but complained to me that all his chicken skin came back on his arms and face too. On this he cleared back up. We both have it a little bit on the upper arms still, but it’s very little and no bother.

  • Sarah Wilson

    2018-02-02 11:46 am

    I had gene testing and it said I had significantly low Methyl folate. I've been taking 15 mg of methyl folate since 2015. I also take a anti-depressant. I ran out about 6 weeks ago and had trouble getting into the site. Finally I signed up again because my depression was coming back. Now I really realize that this does work and I'm reordering today.