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L-Methylfolate 10 mg (from Quatrefolic)

30 CAPS | 10 mg Product No. 00809


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L-Methylfolate 10 mg from Quatrefolic ® offers the newest generation folate: (6S)-5-methyltetrahydrofolate glucosamine salt. Quatrefolic® contains only active S-isomer L-Methylfolate stabilized with vegetable-derived glucosamine HCl. Quatrefolic® has higher solubility, stability, and bioavailability than any other form of folate and we offer this as an additional alternative in our stand-alone formulas. 

  • Supports the production of mood balancing neurotransmitters.
  • Provides most effective form of folate for those with genetic MTHFR variations.
  • Offered in a popular 10 mg strength.


*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

L-Methylfolate 10 mg from Quatrefolic®


Product Code: 00809            Capsules per Bottle: 30


Each size 3 vegetarian cellulose capsule contains:


Folate (10 mg from 18.5 mg L-5-Methylfolate, glucosamine salt)

16.7 mg DFE


210 mg

Other ingredients: vegetarian cellulose capsule.
Quatrefolic® is a registered trademark of Gnosis S.p.A. U.S Patent No. 7,947,662.

Description: L-Methylfolate is the activated form of folate used by the body for many biochemical reactions. Unlike folic acid, L-Methylfolate does not require conversion by the MTHFR enzyme, a function that is impaired by genetic variations present in about half the population. Quatrefolic® has been proven to have greater stability, solubility, and bioactivity than any other form of folate.


Uses: L-Methylfolate is critical for biochemical reactions involving one-carbon transfer (methylation). These include: DNA synthesis, cell division, amino acid metabolism and neurotransmitter synthesis. Studies suggest low folate levels can contribute to depressed mood and that supplementation may be useful for maintenance of healthy moods. A decline in folate levels in the cerebral spinal fluid occurs with aging, and has been associated with reduced cognitive function. L-Methylfolate is essential for the conversion of homocysteine to methionine, supporting vascular and cardio health by lowering homocysteine levels.

In human testing, Quatrefolic® was shown to be 10% more bioavailable than L-Methylfolate, calcium salt.


Source Materials: L-Methylfolate, glucosamine salt (Quatrefolic®, Gnosis Bio, Italy) and glycine are made by chemical synthesis. The glucosamine used is made by fermentation of corn, but no corn is present in the final form. All ingredients are vegan and non-GMO.


Allergens: According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.


Recommendations: Use as directed by a healthcare professional.


Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.



  1. Ginsberg LD et al. L-methylfolate plus SSRI or SNRI from treatment initiation compared to SSRI or SNRI monotherapy in a major depressive episode. Innovations in Clinical Neuroscience. 2011 Jan;8(1): 19-28
  2. Zajecka JM et al. Long-term efficacy, safety, and tolerability of L-methylfolate calcium 15 mg as adjunctive therapy with selective serotonin reuptake inhibitors: a 12 month, open-label study following a placebo-controlled acute study. J Clin Psychiatry. 2016 May; 77(5): 654-60.
  3. Araujo JR et al. Folates and aging: role in mild cognitive impairment, dementia and depression. Ageing Res Rev. 2015 Jul; 22:9-19.
  4. Ambrosino P et al. Cyclic supplementation of 5-MTHF is effective for the correction of hyperhomocysteinemia. Nutr Res. 2015 Jun; 35(6):489-95
  5. Cagnacci A et al. High-dose short-term folate administration modifies ambulatory blood pressure in postmenopausal women. A placebo controlled study. Eur J Clin Nutr. 2009 Oct; 63(10):1266-8.
  6. Ismaili, S. Crossover comparative bioavailability study of 5-methyltetrahydrofolate glucosamine salt compared to reference Metafolin® in healthy volunteers. IPSA-5MTHFA-583-09 Final report, 2010.



These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

L-Methylfolate 10 mg (from Quatrefolic)

Based on scientific research, our L-Methylfolate is a more active and bioavailable form of folate and is the only form of folate to cross the blood-brain-barrier. Use it to help: Support: normal mood* Support: cardio and nerve function* Support: biosynthesis of neurotransmitters *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

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