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B-Complex + 15 mg L-Methylfolate

30 CAPS | 15 mg Product No. 00802


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Our B-Complex products combine our best-selling phosphorylated B-Complex with L-methylfolate from Quatrefolic® in varying doses. These products eliminate the need for additional B-vitamin supplements. Formulated with a full-spectrum of highly bioavailable B-vitamins, our B-Complex formulas include cofactors important for optimal L-methyfolate metabolism, as well as supporting the wide array of metabolic functions requiring these essential nutrients. Use B-Complex + L-Methylfolate to help support healthy mood, cardio, and nerve function.

  • Supports the production of mood balancing neurotransmitters with L-methylfolate and its cofactors.
  • Provides a full spectrum of highly available B vitamins.
  • Supports energy producing processes in several biochemical pathways.

*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

B-Complex + 15 mg L-Methylfolate


Product Code: 00802    Capsules per Bottle: 30  


Each vegetarian cellulose capsules contains:


Vitamin C (as Ascorbyl Palmitate)

15 mg

Thiamine (as Thiamine Mononitrate)

25 mg

Riboflavin (as Riboflavin 5’ Phosphate)

25 mg

Niacin (as Niacinamide)

150 mg NE

Vitamin B-6 (as Pyridoxine HCl and Pyridoxal 5’ Phosphate)

55 mg


(15 mg folate from 27.8 mg L-5-Methylfolate, glucosamine salt)

25 mg DFE

Vitamin B-12 (as Methylcobalamin)

1000 mcg


400 mcg

Pantothenic Acid (as Calcium D-Pantothenate)

150 mg

Choline (as Choline Bitartrate)

50 mg


50 mg

PABA (Para Amino Benzoic Acid)

50 mg

  Other ingredients: vegetarian cellulose capsule


Description: B vitamins are vital to the energy making processes in the body. They are cofactors in the synthesis of thyroid, sex and adrenal hormones. B vitamins assist in the detoxification processes that rid the body of energy depleting substances. They also contribute to energy producing processes in the mitochondria of every cell in the body. B-Complex provides essential nutrients needed for numerous systems and biochemical reactions. Our B-Complex contains the phosphorylated forms of B-2 and B-6 and the methylated forms of B-12 and L-methylfolate for superior bioavailability.

Folic acid, the most common form of folate in supplements and fortified foods, requires the enzyme methylenetetrahydrofolate reductase (MTHFR) to be converted to L-methylfolate, the activated form of folate used by the body for many biochemical reactions. About half of the population have genetic variations that reduce the ability of the MTHFR enzyme to make this conversion. For this population, L-methylfolate supplementation is far more effective in providing this form of folate. It is important to note that all vitamin B levels, especially vitamin B-12, must be adequate when taking L-methylfolate. Otherwise homocysteine cannot be broken down and transformed for neurotransmitter upregulation, even with adequate folate. Supplementing with a B-complex that contains the activated L-methylfolate is a great way to support maximum efficiency of all nutrients.

Uses: B vitamins contained in this supplement blend; thiamine, riboflavin, niacinamide, B-6, biotin, pantothenic acid, folate, and B-12, are commonly associated with energy production, nervous system maintenance, and cardiovascular health. Thiamine, riboflavin, niacinamide, B-6, biotin and pantothenic acid are cofactors for enzymes needed for cellular energy production through metabolism of proteins, carbohydrates, and fats. Thiamine, folate, B-12 are involved in neural development and neurotransmitter synthesis. Inositol was once called B8 and considered a member of the B vitamin family. It shares the qualities of many B vitamins as a stress reducer and mood lifter, although it has more recently been classified as a pseudovitamin, inositol accesses stores of calcium in the brain, in turn activating the release of many neurotransmitters, including serotonin. Inositol also assists in communication between nerves, gene expression, and signal transduction for insulin. All of these functions are closely connected to a healthy CNS, improved cognitive function, clearer thoughts, and a sense of well-being.

Some microbes found in the human gut have the ability to produce folate, an essential nutrient also found in this supplement. Para Amino Benzoic Acid (PABA) is a necessary coenzyme for the production of folate as well as a number of other reactions that are beneficial to digestion.

Methylfolate and B-6 are required for homocysteine metabolism and have been linked to mood improvement. Methylation is a biochemical process involved in almost all of the body’s functions. It is the addition of a single carbon and three hydrogen atoms (called a methyl group) to another molecule. The removal of a methyl group is called demethylation. A healthful diet and adequate nutrition, supported by supplementation, can improve your methylation pathways and boost your health. B vitamins are methyl donors, especially folate, B-6, B-12 and riboflavin, but they cannot be used efficiently by the body unless some critical enzymes are present. One such enzyme is Methylenetetrahydrofolate reductase.

MTHFR is a gene that provides instructions to make an enzyme called methylenetetrahydrofolate reductase. Methylenetetrahydrofolate reductase is a necessary factor for a chemical reaction breaking down folate (folic acid/vitamin B-9) to its active form, L-methylfolate (5-MTHF). Specifically, this enzyme converts a molecule called 5,10-methylenetetrahydrofolate to a molecule called 5-methyltetrahydrofolate. This reaction is also required to convert the amino acid homocysteine to another amino acid, methionine. The body uses methionine to make proteins such as the neurotransmitters; dopamine, serotonin, melatonin, and epinephrine. It is through this pathway, that L-methylfolate has a regulatory effect on mood.

It has been estimated that up to 60% of Americans carry an inherited mutation in the MTHFR gene. While many people with mutations in this gene will live a normal life without experiencing symptoms, some individuals experience a drop in enzyme efficiency by 30-70%, depending on the variant of the mutation. If this is the case, folate cannot be converted to L-methylfolate, homocysteine will not be efficiently broken down into methionine, and the production of neurotransmitters may slow, dramatically affecting mood. Unconverted folate and homocysteine levels build up in the blood without consistent conversion, and elevated homocysteine in the blood is a known, independent risk factor for heart disease, stroke, and other forms of cardiovascular disease.

Only a genetic test by your doctor can confirm whether or not you have a MTHFR mutation, but if you do, L-methylfolate supplementation could be the answer. L-Methylfolate bypasses the entire folic acid metabolism cycle and has been shown to be more effective than folic acid for increasing circulating folate in those with an MTHFR mutation. L-Methylfolate is also highly effective at reducing homocysteine levels in healthy people (without an MTHFR mutation). It is better absorbed and interacts with fewer medications than folic acid.

Source Materials: 

Allergens:  According to information provided by our suppliers, these capsules are free of the eight major allergens as identified by the Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA): Wheat (gluten), eggs, milk, soybeans, shellfish, fish, peanuts, tree nuts.

Recommendations: Use as directed by a healthcare professional.

Precautions: Pregnant or lactating women and individuals taking prescription medications should consult with a healthcare professional before taking any supplement.


Bauerly K, Rucker RB. Pantothenic acid. In: Zempleni J, Rucker RB, McCormick DB, Suttie JW, eds. Handbook of vitamins. 4th ed. Boca Raton: CRC Press; 2007:289-314.

Bottiglieri, Teodoro, et al. "Homocysteine, folate, methylation, and monoamine metabolism in depression." Journal of Neurology, Neurosurgery & Psychiatry 69.2 (2000): 228-232.

LeBano, Lauren. “L-Methylfolate: A Promising Therapy for Treatment-Resistant Depression?” Psyche Congress Network. May 8, 2013. www.psychcongress.com/article/l-methylfolate-promising-therapy-treatment-resistant-depression

Leech, Joe. “L-Methylfolate (5-MTHF): Your Must-Read Beginner’s Guide.” Diet vs. Disease. May 13, 2018. https://www.dietvsdisease.org/l-methylfolate-5-mthf/

Papakostas, George I., et al. "L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials." American Journal of Psychiatry 169.12 (2012): 1267-1274.

Patanwala, Imran, et al. "Folic acid handling by the human gut: implications for food fortification and supplementation–."The American journal of clinical nutrition 100.2 (2014): 593-599.

Selhub, Jacob, et al. "B vitamins, homocysteine, and neurocognitive function in the elderly–." The American journal of clinical nutrition 71.2 (2000): 614S-620S.

Stahl, Stephen M. "Brainstorms: L-Methylfolate: A Vitamin for Your Monoamines." The Journal of clinical psychiatry 69.9 (2008): 1352-1353.

Wegkamp, Arno, et al. "Characterization of the role of para-aminobenzoic acid biosynthesis in folate production by Lactococcus lactis." Applied and environmental microbiology73.8 (2007): 2673-2681.

Wilson MS, et al., “Inositol pyrophosphates: between signalling and metabolism.” Biochem J. 2013.


These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

B-Complex + 15 mg L-Methylfolate

Based on scientific research, our L-Methylfolate is a more active and bioavailable form of folate and is the only form of folate to cross the blood-brain-barrier. Use it to help: Support: normal mood* Support: cardio and nerve function* Support: biosynthesis of neurotransmitters *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

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  • Alyssa S

    2021-11-28 06:33 am

    I notice a huge difference in my energy and depression within days. Definitely, worth the money!

  • Maggie Owensby

    2020-07-09 10:38 pm

    I love this vitamin complex. I took it years ago when I was very ill and noticed a HUGE difference when I was taking it. It was the only thing that gave me any bit of energy..

    I ended up getting so sick that I fell off the bandwagon with this supplement. I had too many other medical bills I just couldn’t afford it.

    Recently I’ve started taking it again and wow what a difference. I plan to never be without this supplement. I am on medications to treat bipolar disorder, anxiety, depression, and my MAIN issue, OCD (I know I sound like a real peach) and this supplement is amazing in conjunction with my prescriptions. I notice it really makes me a lot happier naturally :) thank you for a great product

  • Norman Leonard

    2018-11-07 06:49 am

    Excellent product and very helpful for managing my anxiety and depression.

  • Jennifer House

    2018-10-05 10:01 am

    I took a genetics test in 2013 because I wasn't responding to my bipolar medications. Turns out I also have 5-MTHF mutation and have been taking Deplin since, when I could afford it. For a short while I was able to purchase it with insurance at certain pharmacies. When the law passed that said a patient shouldn't need a RX for a vitamin my ARNP told me about this site. I ordered the straight L-Methyl as that was all I could afford. Shipping was fast and the product didn't seem any different then Deplin. I read the other review about this blend and had some extra money a few times back that I reordered so I decided to try to the B complex with L-Methyl. I love this blend! I've never noticed a difference in feeling after taking B complex until now. I can't explain it I just feel better when I take it! I'm so glad I tried it. Thank you!

  • Cammie Beierle

    2018-02-17 09:21 pm

    I have taken folate supplements for over 40 years. When I was diagnosed with an autoimmune disease 14 years ago (my first symptom was 30 years ago), they recommended that i not take supplements that would build up my immune system. I refused to stop and this disease has had little effect even though on paper I should not be healthy at all. My family treats anxiety and depression with this supplement. I am 64 and I run circles around my peers and younger because of the endurance I gain from this supplement. This formula replaces probably 3 other supplements I was taking. I recommend it to many people. This company provides a quality and reasonably priced form of folate.